While definitive findings concerning sucralose side effects remain unknown, as of 2015, research links ingestion of this artificial sweetener to metabolic syndrome, according to the American Diabetes Association. Metabolic syndrome causes excess build-up of fat around the midsection, a spike in bad cholesterol that remains high, consistent high blood pressure and high blood sugar levels, states HealthResearchFunding.org. Other reported side effects include migraines, feelings of vertigo, nausea and allergic reactions.
In 2013, the Center for Science in the Public Interest removed the "Safe" label from sucralose, replacing it with a "Caution" label due to research linking sucralose ingestion to leukemia in mice, states the CSPI. Further review is necessary before the group determines if sucralose is safe to include in food, as of 2015. This study, conducted by Dr. Morando Soffritti, director of the Ramazzini Institute in Bologna, Italy, found a lifetime of sucralose consumption linked to an increase risk of leukemia, explains Medical News Today.
The U.S. Food and Drug Administration continues to label sucralose, marketed as Splenda, as safe, states the FDA. However, research links the sweetener to lower levels of healthy gut bacteria, states HealthResearchFunding.org. Ingesting sucralose can lower these levels by as much as 50 percent. This, in turn, causes higher P-glycoprotein levels, which interferes with medications and medical treatments for those with severe health conditions, such as cancer or heart disease.
Insulin, a hormone secreted by the pancreas, assists with the absorption and storage of sugar, or glucose, in the bloodstream, according to the Huffington Post. The amount of insulin produced is proportional to how much sugar is circulating. In healthy individuals, more sugar in the bloodstream means a higher level of insulin is produced in order to manage it. Individuals with Type 2 diabetes have a higher level of resistance to insulin, causing sugar to build up and remain in the bloodstream.