Some side effects of using Splenda can include migraines, bloating, rashes, hives, dizziness and intestinal cramping. Consuming large amounts of Splenda may also cause diarrhea, notes MedicineNet.
The use of chlorine in Splenda production is the cause of most side effects associated with this artificial sweetener, notes DrAxe.com. A number of studies classify chlorine as a carcinogen.
Almost all Splenda passes through the body undigested, which is why it is a zero-calorie sweetener; however, studies indicate that around 3 percent of consumed Splenda may stay in the body with moderate use. This number increases to around 8 percent with heavy consumption, notes DrAxe.com. The long-term impact of chlorine being stored in the body is still unclear.