Meatloaf is done when a meat thermometer inserted in its center reads 160 degrees Fahrenheit. Ground beef used for food items like hamburgers or meatloaf should be at this temperature after it is cooked. Eating undercooked ground beef can lead to E.coli poisoning, according to KidsHealth.
Meatloaf is a dish that may contain ground beef and other ground meats combined with ingredients like breadcrumbs, eggs, onions, garlic, spices and carrots. The meat is shaped into a loaf and baked in a pre-heated oven at 325 degrees Fahrenheit. The meatloaf should cook for approximately 45 minutes before checking the internal temperature of the meat with a thermometer.