Bone-in pork loin may be roasted at 350 degrees Fahrenheit for 25 to 40 minutes per pound (100 to 160 minutes for a 4-pound loin), while a boneless loin should be roasted for 20 to 25 minutes per pound (80 to 100 minutes for a 4-pound loin).
The cooking time of pork loin varies depending on the weight, cooking method, temperature, and whether bone is present, as reported by the National Pork Board on its Pork Be Inspired website. Popular cooking methods include roasting and barbecuing. Additionally, pork loin can be cut before sautéing, braising, or stewing. Barbecued pork loin cooked at approximately 325 degrees Fahrenheit will take 14 to 17 minutes per pound for bone-in and 12 to 15 minutes per pound for boneless. For best results, ensure that the internal temperature after a 3 minute rest is 145 to 160 degrees Fahrenheit before consuming.