A popular recipe for a pizza casserole bake uses biscuit dough as the crust. To prepare, open a 16-ounce can of refrigerated biscuit dough and cut each biscuit into eight pieces. Mix the dough with a 8-ounce can of pizza sauce and 1 cup of shredded mozzarella cheese.
Spray a 13x9-inch baking dish with vegetable spray and spread the dough mixture across the bottom. Top the dough with 16 slices of pepperoni and 1 cup of mozzarella cheese. Bake the casserole at 375 degrees Fahrenheit for approximately 20 minutes, until it browns and the cheese is bubbly.
Another popular version of pizza casserole uses pasta instead of bread for the crust. Bring a large pot of salted water to a boil and add 16 ounces of dry rotini pasta. Cook the pasta for eight to 10 minutes, until it is cooked al dente.
Brown 1 pound of ground Italian sausage in a skillet over medium heat, then drain the excess fat. Stir in the cooked pasta and 1 jar of pasta sauce and transfer the mixture into a lightly greased 13x9-inch casserole dish.
Mix a 16-ounce container of cottage cheese, 1 small can of drained sliced olives, a 4-ounce can of mushrooms and 12 ounces of mozzarella cheese in a large bowl. Evenly spoon the cheese mixture over the sausage and pasta and top the casserole with 3 ounces of sliced pepperoni. Bake for 25 minutes at 350 degrees Fahrenheit until the casserole is lightly browned.