The dangers of aspartame, acesulfame, sucralose and other artificial sweeteners relate to interactions that interfere with body chemistry and digestive processes. As of 2015 acesulfame, sucralose and aspartame have all been deemed safe for human consumption. There is, however, significant controversy surrounding the presence of artificial sweeteners in processed foods.
For people with Phenylketonuria, aspartame is dangerous because it contains high quantities of phenylalanine. Sucralose is thought to be dangerous because it contains chlorine, which is considered a carcinogen, and because of a lack of research on its effects. Acesulfame is considered dangerous because it contains methyl-chloride, also a known carcinogen.
Because artificial sweeteners taste many times sweeter than natural sugars, they can, over time, cause the taste buds to adapt, causing people to seek out foods with artificial sweeteners in them and avoid natural sugars for lack of sweetness. This can result in the decreased consumption of fruits and an increased consumption of processed foods which are less nutritious. Artificial sweeteners are touted for containing no calories, but in fact the absence of calories can cause a person to gain weight by increasing cravings. In addition, artificial sweeteners increase insulin production, leading to blood sugar spikes and further hunger pangs.