The estimated cooking time for a classic meatloaf is 1 hour. This cooking time is used when the meatloaf is cooked in an oven set to 375 degrees Fahrenheit.
The cooking times can vary slightly by recipe and the size of the meatloaf. Some recipes state to cook a 2-lb. meatloaf in an oven set to 400 degrees for 45 to 55 minutes.
The meatloaf is done cooking when it reaches an internal temperature of 160 degrees. The temperature of the meat can be taken using a cooking thermometer.
Once the meatloaf has cooked it should be allowed to rest for 10 minutes before serving.