Despite its popularity as a digestive aid, no scientific evidence exists to support the use of apple cider vinegar to alleviate acid reflux as of 2015, says About.com. Vinegar is an acid, and it can damage the esophagus or stomach when taken as a liquid or in pill form.
Preliminary research indicates that apple cider vinegar has some benefits, such as controlling high cholesterol and helping with weight loss, says About.com. However, other remedies are better for acid reflux, explains Mehmet Oz, M.D. For instance, melatonin taken two hours before bedtime helps to protect the stomach lining and keep the esophageal sphincter closed during sleep, while baking soda dissolved in water neutralizes stomach acid for fast relief. Losing weight, sleeping with the head of the bed elevated and chewing deglycyrrhizinated licorice tablets 20 minutes before meals sometimes helps as well.