The Spanish question "Que es el lupus?" is translated as "What is lupus?" in English. This question can be found on the Lupus Foundation of America website, which has a version of its site for Spanish speakers.
The word for word literal translation of "Que es el lupus?" can be broken into four words. The word "que" means "that," while "es" is a verb meaning "to be." "El" is the article used before a masculine noun and is translated as "the." Lupus is the word for a specific disease and is used in both English and Spanish. If "que es el lupus" was a sentence, it would translate as "that is lupus." When it is in the form of a question, "that" becomes "what."