As of 2015, St. Vincent Medical Center is located in downtown Los Angeles at 2131 West Third Street, Los Angeles, CA, 90057. It is on the corner of West Third and Alvarado Street.
Coming from the north, take the Hollywood 101 Freeway south and exit at Alvarado Street. From the east, take the San Bernardino 10 Freeway to the Harbor 110 Freeway and exit at West Third Street. From the south, take the Harbor 110 Freeway north and exit onto West Third Street, similar to arriving from the east. If you're driving west, take the Santa Monica 10 Freeway to the Harbor 110 Freeway north before arriving at the West Third Street exit.