Factors that influence the value of American $2 bank notes include the condition, serial number, age and signature combination. Large-size $2 notes from before 1928 are particularly valuable when referring to these four factors. The condition of the note is the most important factor.
Owners should find the date of the $2 bill, which sometimes can be hard to find. Each note has the signature of the Secretary of the Treasury and the Treasurer of the United States. Certain signature combinations are rarer than others because some signatures were on small print runs.
Uncirculated notes are the most coveted $2 bills printed before 1928. For example, $2 bills printed in 1862 are worth anywhere from $200 in circulated condition to $1,000 for examples that have a lot of "eye appeal," as of February 2015. The serial numbers on 1862 notes only went up to 99999. However, a bill printed in 1963 may sell for $8 in perfect condition and $3 in circulated condition because these notes are quite common.
Every $2 bill printed from 1869 onward features Thomas Jefferson on the front. Bank notes printed from 1976 onward have an engraving of the signing of the Declaration of Independence on the back. These bills do not have regular printings, unlike other denominations. Bills printed in 1862 have Alexander Hamilton on the front.