According to the Bureau of Engraving and Printing, Thomas Jefferson's portrait is on the front of the $2 bill. This source notes that the back of the $2 bill features John Trumbull's painting "The Signing of the Declaration of Independence."
MSN Money explains that the original $2 bill, introduced in 1862, displayed a portrait of Alexander Hamilton, but it was replaced with Jefferson's portrait in 1869. In 1928, Jefferson's home, Monticello, was first added to the reverse side of the $2 bill, according to the Bureau of Engraving and Printing.
MSN Money states that the $2 bill was never very popular and was discontinued in 1966; however, it was reinstated in 1976 as part of the U.S. Bicentennial celebration. MSN Money notes that at the dawn of the 21st century, over $1.1 billion worth of the bills were in circulation, and 230 million $2 bills were printed in 2006.