As of 2015, some of the larger companies listed in the Russell 2000 are Isis Pharmaceuticals, WEX, Team Health Holdings, Ultimate Software Group and The RLJ Companies. As the Russell 2000 is a small-cap index of the bottom 2,000 stocks in the Russell 3000 index, it generally does not contain companies that are well-known outside of finance or their specialized industries.
Isis Pharmaceuticals develops drugs for the treatment of various diseases and conditions, such as high cholesterol and neurological disorders. The company is headquartered in Carlsbad, California.
WEX, a payment processing company, owns MasterCard as well as the Fleet payment processing service used for vehicle fleet industries.
Team Health Holdings is the parent company of TeamHealth, one of the largest hospital staffing firms in the United States. It is a Fortune 1000 company headquartered in Knoxville, Tennessee.
Ultimate Software Group is primarily known for the human resources software management system UltiPro. It is headquartered in Weston, Florida.
The RLJ Companies is an asset management firm with a diverse range of interests including financial services, insurance, car dealerships and video lottery terminals. The company was formerly named RLJ Lodging Trust as it was centered around the ownership of a number of upscale hotel brands such as Courtyard by Marriott and Hilton Garden Inn.