Apply Tri-Luma Cream to the face at least 30 minutes before bedtime. Do not apply more Tri-Luma Cream than recommended by your doctor. Doing so makes no difference in the results and may irritate the skin, according to the cream's manufacturer.
Use your fingers to wash your face with a mild cleanser, and pat the skin dry before applying Tri-Luma Cream. After placing a thin layer of Tri-Luma Cream onto the discolored spots on the face along with 1/2 inch of the surrounding area, rub the medicine into the skin to make it transparent. Tri-Luma Cream should not be applied to any open wounds and kept away from the eyes, mouth and corners of the nose to prevent irritation. Use sunscreen with an SPF of 30 or more and a wide-brimmed hat to protect treated skin from any amount of sunlight when the product is in use, and continue to protect the skin from sunlight after treatment. Face moisturizers and cosmetics are allowed with the use of Tri-Luma Cream.
Possible side effects of using Tri-Luma Cream include redness, burning, dryness, itching and peeling. The manufacturer recommends discontinuing its use immediately and to contact your doctor if Tri-Luma Cream causes a blue-black hyper-pigmentation.