Antiperspirants can be applied to sweaty hands to block perspiration. Using an over-the-counter antiperspirant is generally less irritating, but it may not be effective. In that case, a dermatologist can prescribe a prescription antiperspirant. Other methods of getting rid of sweaty hands include iontophoresis, Botox injections, anticholinergic drugs and surgery.
In iontophoresis, the hands are placed in a shallow tray of water with an electric current running through it. This blocks the sweat glands. Anticholinergic drugs also work by blocking the sweat glands.
Botox injections deactivate the chemicals that tell sweat glands to produce sweat. These injections may last up to one year.
Surgical removal of the sweat glands is a last-resort treatment. This surgery can leave scars and cause sweating in other areas of the body.