The most effective over-the-counter wrinkle creams are those that contain retinol. Less expensive and less irritating than its prescription counterpart, Retin-A, retinol has a gentle exfoliating effect. It helps with collagen production and improves the appearance of fine lines.
For those new to retinol products, dermatologists recommend using small amounts and applying on alternate days to get accustomed to the exfoliation effects without causing irritation. Retinol's rejuvenating effect and the resulting improved appearance are typically seen within eight weeks from the start of the program of use. Because retinol is photosensitive, it should be applied as a nighttime skin-care routine.