ST&T Research conducted clinical trials suggesting that Nerium's main ingredient was effective, according to Nerium Biotechnology. However, this study has not been published in any peer-reviewed publication on PubMed, according Dr. Jen Gunter's website. There are many positive and negative reviews for Nerium AD on Amazon.com and WebMD.
Nerium AD is made with the leaves of the Nerium oleander plant, which has been used for medicinal
purposes for more than a thousand years and was known for its beneficial effects on the skin, according to Nerium Biotechnology. Nerium oleander is toxic and potentially fatal when ingested, according to WebMD. Potential negative side effects include inflammation, rashes, swelling, dryness and itchiness, as noted by WebMD user reviews.