Common side effects of ibrutinib include constipation, diarrhea, nausea, vomiting and stomach pain, according to MedlinePlus. Patients may also experience heartburn, loss of appetite, tiredness, muscle spasms or shortness of breath.
Additional side effects of ibrutinib include itching, rash, dizziness, anxiety and difficulty sleeping, as stated by MedlinePlus. Patients may experience pain in the bones, muscles or joints, and they may develop sores in the throat or mouth. The hands, lower legs, ankles or feet may become swollen. Patients should contact their doctor if these symptoms are bothersome or don't disappear on their own.
Serious side effects may include unusual bleeding or bruising, stools that are bloody or tarry, nosebleeds, a fast heartbeat and chest discomfort, as listed by MedlinePlus. Other serious side effects include vision changes, speech changes, confusion, decreased urination and persistent headache. Urine may become red, pink or dark brown, and vomit may include blood or a dark material that looks like coffee grounds. Patients may become lightheaded or faint, and some patients exhibit signs of infection, such as cough, fever and chills. Patients should seek emergency medical attention if they experience any of these side effects. Ibrutinib may also increase the risk of developing skin cancer and certain other types of cancer.