The three witches predicted that Macbeth would become King of Scotland. Macbeth becomes obsessed with this fate, and under the influence of his power-hungry wife, Lady Macbeth, he speeds up his fate by murdering the king.
After Macbeth murders King Duncan, Duncan's heir, Malcolm, flees the country. He later returns with the support of another of the Scottish Thanes, Macduff, and reclaims the crown from Macbeth.
The witches also predict that although Macbeth is to be king, any future king is to come from the bloodline of Macbeth's friend Banquo. Macbeth hires assassins to murder Banquo and Banquo's son Fleance, however Fleance survives and flees.
The final prophecy of the witches is that Macbeth would only die by the hand of a man who was "not born of woman." It is revealed that Macduff was born by cesarean birth, completing the prophecy.