Tom and Daisy of F. Scott Fitzgerald's "The Great Gatsby" leave town after Gatsby's death because of their infidelities. Tom had several affairs with women, including a chambermaid and Myrtle Wilson. Daisy was furious with her husband but continued to ignore his behavior until she reunited with Jay Gatsby, according to CliffsNotes.
During the length of the novel, the reader discovers that Jay Gatsby and Daisy were in love many years ago. When they meet in Chicago, they rekindle their affair. At the same time, Tom is having an affair with Myrtle.
Both Myrtle Wilson and Jay Gatsby are murdered in the last few chapters of the story. Myrtle is hit and killed with Gatsby's car and her husband shoots Gatsby at his mansion. With both lovers gone, Tom and Daisy disappear from the unraveling chaos.
As Nick arranges the funeral, he learns that Tom and Daisy fled Chicago without leaving a forwarding address. It seems that they fled the embarrassment of their affairs as Jay Gatsby's life was becoming the media's center of attention.
Several sections of the book point to Tom and Daisy having a habit of leaving a town to avoid the consequences of Tom's infidelity. Chapter four and chapter seven give direct quotes about why they kept relocating.