"The Power of Six" by Pittacus Lore is rated 4.17 out of five by GoodReads.com from 89,000 ratings, as of December 2015. There are 655 reviews on Amazon.com, giving the book an average score of 4.5 stars out of five.
For 10 weeks, the book remained on the New York Times Best Seller list. Alaisdair Dewar, writing for FantasyBookReview.co.uk, praised the book for its sophisticated storytelling and called it "an engaging story that stands out as one of the best sci-fi novels I have ever read." Stephen Lackey of GeeksofDoom.com, though he complained about the predictable love triangle, said that he was excited by the action and enjoyed the interesting and entertaining character development.