As of 2015, the primary members of the "Mike & Molly" cast are Billy Gardell and Melissa McCarthy. Gardell plays Mike Biggs, a Chicago police officer. McCarthy plays Molly Flynn, a fourth-grade teacher.
As of 2015, three additional members of the "Mike & Molly" cast who have appeared in every episode are Reno Wilson, Katy Mixon and Swoosie Kurtz. Wilson portrays Carl McMillan, a police officer and Mike's best friend. Mixon plays Victoria Flynn, Molly's party-girl sister. Kurtz portrays Joyce Moranto, the mother of Molly and Victoria. Another major cast member is Nyambi Nyambi, who plays Samuel, a waiter at a restaurant where Mike and Carl regularly eat.