Some of the main characters in "The Smurfs" are the title characters, including Papa Smurf, Clumsy Smurf, Brainy Smurf and Smurfette. In addition to the Smurfs, the film features human characters such as Gargamel, Pat Winslow and Grace Winslow.
Papa Smurf, the leader of the Smurfs, is voiced by Jonathan Winters. He leads the other Smurfs, including Brainy Smurf, voiced by Fred Armisen, Clumsy Smurf, voiced by Anton Yelchin, and Smurfette, voiced by Katy Perry. The plot of "The Smurfs" focuses on the title characters defeating the villainous Gargamel, a human played by Hank Azaria. The Smurfs received assistance in their endeavors from Pat and Grace Winslow, a married couple played by Neil Patrick Harris and Jayma Mays, respectively.