There are many famous and memorable radio commercials. Old-Time.com lists famous and unique radio commercials from the 1920s through the 1950s. The website includes detailed historical information about each commercial and audio recordings of some of the commercials. RadioMercuryAwards.org lists modern radio commercial award winners from 1992 to 2014.
The first commercial broadcast on the radio was unique because at the time, direct selling was illegal. The commercial consisted of indirect advertising for an apartment complex with a segment talking about how great it was to live in the Hawthorne Court apartment complex. The Coca Cola Hour was an innovative radio advertising idea from the 1930s in which a whole radio program was sponsored by the company. Camel cigarettes launched an infamous commercial campaign in the 1940s in which doctors recommended smoking the company's cigarettes over other brands.
Dos Equis produced a more modern famous radio commercial in 2011 featuring its "Most Interesting Man in the World" character flying to Columbia just to get a great morning cup of coffee. Old Spice's Momsong advertisement is another famous modern commercial featuring mothers comically following their sons around and singing about their sons growing up as the sons go through teenage rites of passage.