The main character for "Charlotte's Web" by E.B. White is the spider named Charlotte. The next main character is Wilbur, the pig. Wilbur and Charlotte become good friends as Charlotte helps Wilbur devise a plan keep Wilbur from being butchered at the end of the season.
The Arable family owns Wilbur. Wilbur's first owner is John, but John's daughter Fern adopts the runt Wilbur in his infancy. She takes care of him and is the only human who understands the speech of the animals. Avery is Fern's brother and is often providing comic relief. Homer Zuckerman owns the farm where Wilbur eventually lives. He is Fern's uncle. Zuckerman's wife is Edith, and Lurvy is the assistant.
Another animal in the book who also happens to provide comic relief is Templeton. He is a rat who is motivated only by food to help Charlotte and Wilbur. Charlotte makes Wilbur look impressive and not a pig that needs to be slaughtered by weaving compliments about Wilbur into her web. Zuckerman's neighbors believe this to be a sign from above. Wilbur is entered into the county fair and is so loved that everyone believes him not worthy of being slaughtered.
Even after Charlotte dies, Wilbur becomes friends with a few of her offspring, who are able to continue to help keep Wilbur alive for many years.