New Data Available

We have added new links to the download section:
  • HMM libraries
  • CATH Domain PDB libraries
...more


CATH v3.2.0 Released

The latest release of CATH (version 3.2.0) was fixed on July 14, 2008 and contains 114215 assigned domains. ...more


New Look CATH

The release of CATH v3.2.0 brings with it shiny new web pages. We hope you find these pages clearer and more intuitive to use. If you can't find the data that you are looking for then please do let us know. ...more


CATH: Protein Structure Classification

Thumbnail displaying an overview of the CATH hierarchy

Introduction

CATH is a hierarchical classification of protein domain structures, which clusters proteins at four major levels: Class (C), Architecture (A), Topology (T) and Homologous superfamily (H). The boundaries and assignments for each protein domain are determined using a combination of automated and manual procedures which include computational techniques, empirical and statistical evidence, literature review and expert analysis. more...

Links for Researchers

Links for Developers

CATH References

The CATH classification revisited--architectures reviewed and new ways to characterize structural divergence in superfamilies. Alison L. Cuff; Ian Sillitoe; Tony Lewis; Oliver C. Redfern; Richard Garratt; Janet Thornton; Christine A. Orengo (2008) Nucleic Acids Research
CATH: A Hierarchic Classification of Protein Domain Structures. Orengo,C.A., Michie,A.D., Jones,D.T., Swindells,M.B., Thornton,J.M. (1997). Structure, 5, 1093-1108 PubMed icon
...all Orengo group publications