She and Sheila Smythe are best friends and spend a lot of time together. Many times, they find themselves trying to break up fights between their husbands. Like Sheila, Wilma wants her son and Sheila's daughter, Samantha Smythe, to remain a couple, despite Samson's attempts to break them up.
In 2005, it was revealed that Wilma and Jughead Jones' mother, Gladys Jones, are sisters, which makes her Jughead's aunt. This, in essence, ties the Wilkin and Smythe families in with the larger Archie Comics universe.