He is the twin brother of soap opera actor Kin Shriner and the son of Herb Shriner, a Hoosier humorist who had several shows in the early days of television including Two for the Money and The Herb Shriner Show. Wil made his first appearance on The Tonight Show with David Letterman and then went on to be a regular on the NBC morning show The David Letterman Show. For one season in the 1980s (1987-88), he hosted The Wil Shriner Show, a nationally-syndicated television talk show. He also hosted two game shows, one was the American version of That's My Dog and Small Talk. Also a show about inventors Why Didn't I Think of That that ran for two years. He spent four years as a corespondent and guest host on the ABC network morning show Home Show.
He began directing sitcoms in 2000 with his start at Frasier, and Becker to Everyone Loves Raymond. He also did episodes of Raising Dad, My Wife and Kids, Norm, Married to the Kellys, Luis, Ladies Man, Two Guys and A Girl, and Living with Fran.
In 2006, he wrote the screenplay and directed the feature film HOOT which was released by New Line Cinema on over 3000 screens. The family film came out on DVD in August 2007 and continue to entertain kids with the beauty of Florida and the message of stepping up when they see wrongdoing.
He recently directed an episode of The Gilmore Girls that airs on the CW.
He continues to do stand up comedy around the country and in the corporate arenas while working on his next film project.