Bugliosi, who is of Italian ancestry, is married with two children: Wendy and Vince Jr. He often refers to his wife, Gail, in his books, referencing her understanding and patience with him. He has also stated that he is an agnostic, although open to the ideas of deism.
Bugliosi was very critical of prosecutors Marcia Clark and Christopher Darden and pointed out many glaring mistakes that they had made during the trial. He faulted them, for example, for not introducing the note that Simpson had written before trying to flee. Bugliosi said that the note "reeked" of guilt and that the jury should have been allowed to see it. He also pointed out that there was a change of clothing, a large amount of cash, a passport and a disguise kit found in the Bronco of which the jury was never informed.
Simpson had made a very incriminating statement to police about cutting his finger the night of the murders. Bugliosi once again took Clark and Darden to task for not allowing the jury to hear the tape of this statement.
Bugliosi also said the prosecutors should have gone into more detail about Simpson's abuse of his wife. He said it should have been made clear to the mostly African-American jury that Simpson had little impact in the black community and had done nothing to help blacks less fortunate than him. Bugliosi pointed out that, although the prosecutors obviously understood that Simpson's race had nothing to do with the murders, once the defense "opened the door" by trying to paint Simpson falsely as a "leader" in the black community, the evidence to the contrary should have been presented, to prevent the jury from allowing it to bias their verdict.
He also has stated that, if he were prosecuting this case, he would have put at least 500 hours of preparation into his final summation, and that it was obvious that Clark and Darden had waited until the night before to prepare for it.
Bugliosi also spoke at length about the allegations that LAPD detective Mark Fuhrman had planted a bloody glove in order to frame Simpson. He argued that in order for Fuhrman to pull this off, there would have had to have been a broad-reaching conspiracy between Fuhrman and the other officers who worked the case. Indeed, while the defense made much of Fuhrman's racial slurs, it never proved that anyone planted evidence in the case.
Bugliosi also pointed out that it was highly improbable that Fuhrman and anyone else involved in the case would have tried to frame Simpson, as California law of the time provided that anyone who planted evidence in a death penalty case could have faced the death penalty themselves.
He also believes that George W. Bush should be charged with the murders of over 4,000 American soldiers as well as over 100,000 Iraqis who have died in Iraq since the American-led invasion of that country because of the strong evidence that Bush launched that invasion under false pretenses. He has recently released a book, The Prosecution of George W. Bush for Murder, laying out this evidence and outlining what questions he would ask Bush at a potential murder trial. Bugliosi gave testimony at a House Judiciary Committee meeting on July 25, 2008, to consider impeachment proceedings for Bush.
Bugliosi is also a serious student of the John F. Kennedy assassination. In 1986, he played the part of prosecutor in an unscripted 21-hour television trial of Lee Harvey Oswald. The program, sponsored by London Weekend Television, required extensive preparations by Bugliosi and inspired him to later write a comprehensive book on the subject of the assassination. His 1612-page book (with a CD-ROM containing an additional 958 pages of endnotes and 170 pages of source notes), Reclaiming History: The Assassination of President John F. Kennedy was published in May 2007. His book examines the JFK assassination in detail and draws on a variety of sources; his findings are in line with those of the Warren Report which concluded that Lee Harvey Oswald acted alone in the assassination of the president. He has called Reclaiming History his "magnum-opus". A comprehensive essay attempting to refuteReclaiming History was written by Michael Green in 2007 and posted online to a 9/11 conspiracy theory website.