Tylenol PM is the trademark for a mixture of paracetamol (acetaminophen) and diphenhydramine, distributed by Johnson & Johnson. It is marketed as a combined analgesic and sedative, or more simply, pain reliever and sleep aid, intended to treat occasional headaches and minor aches and pains with accompanying sleeplessness. It is listed as non-habit forming.

Acetaminophen alone is sold as simply Tylenol, while diphenhydramine alone is marketed as Simply Sleep, and as Benadryl.

Diphenhydramine is an antihistamine and is also the active ingredient in Benadryl (allergies) and Benylin which is used in cough and cold therapy as an anti-cough (anti-tussive) with the drying effect of the anti-histamine. The drowsiness is caused by the antihistamine.