TPI plays an important role in glycolysis and is essential for efficient energy production. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI.
In humans, deficiencies in TPI are associated with a progressive, severe neurological disorder called Triose Phosphate Isomerase deficiency.
Triose phosphate isomerase is a highly efficient enzyme, performing the reaction billions of times faster than it would occur naturally in solution. The reaction is so efficient it is limited only by the rate the substrate can diffuse into the enzyme's active site.
Sequencing and genotypic analysis of the triosephosphate isomerase ( TPI1 ) locus in a large sample of long-lived Germans.(Research article)
May 29, 2008; Authors: Markus Ralser ; Almut Nebel ; Rabea Kleindorp ; Sylvia Krobitsch ; Hans Lehrach ; Stefan Schreiber ;...