The intention being to address the elusive boy's magazine market. By including reviews of DVDs, PC games, movies, sport features and the like, combined with irreverent toilet humour and original comic strips, the magazine proved to be extremely successful and continues to be published.
Toxic is "edited" by Team Toxic, a group of creatures under the supervision of Doc Shock. (Although in reality, Toxic is edited by Matt Yeo). Designed by the cartoonist Jon Rushby Team Toxic also appear in a regular two page comic strip in the magazine, written and drawn by Lew Stringer. Other comic strips include Grott the Mighty by Nigel Kitching,Rex written by John A. Short and drawn by Alex Paterson and starting in issue 116 Robin Hoodie by John A. Short and artist Laura Howell. Matt Yeo has stated, in an interview with John Freeman, "I've always said from day one that the comic content of TOXIC is essential to its success".
Initially launched as a monthly title, Toxic increased frequency to every three weeks with issue 14, then to fortnightly with issue 34.
Another magazine by the same name was launched in January 2005 with a focus on content for men. That Toxic magazine is currently being published as a major online publication since February 2006.