At Western, he illustrated primarily Disney comics, especially from the Duck universe. Starting with a Bucky Bug story for Walt Disney's Comics and Stories #100 in 1949, Strobl had a long and impressive production of Disney comics. He did comics for the American market until 1968, and comics with Disney characters for foreign markets from 1963 to his retirement in 1987. This was for a little known special unit set up by Disney to provide material for their foreign comics licensees (some of whom had titles published weekly and were quickly burning through the backlog of materials published by Western, which also reduced its output of new material by the mid-1960s). Although during his career he primarily illustrated stories written by others, he wrote some of his stories himself. Strobl also illustrated some stories written by Carl Barks after the latter's 1966 retirement. The most significant of these is "King Scrooge the First" (Uncle Scrooge #71).
In the Hall of Fame series of hardcover books devoted to the greatest Duck (and Mouse) comics artists, published in Norwegian, Danish and Swedish by Egmont, Volume 15 (2006) is dedicated to Strobl's work.
In 1942, Strobl saved a seven year old girl from drowning.