• Tommy Thompson, former United States Secretary of Health and Human Services
• Tommy Thompson (football player), an American football player in the NFL
• Tommy Thompson (footballer), (born 1929) former England and Aston Villa footballer
• Tom Thompson (footballer born 1894), another English footballer
• Thomas Thompson (New Zealand) (1832–1919), a New Zealand politician
• Thomas Gordon Thompson (1888–1961), American chemist and oceanographer
• Thomas Larkin Thompson (1838–1898), United States Representative from California, ambassador to Brazil
• Thomas L. Thompson (born 1939), American biblical scholar
• Thomas Perronet Thompson (1783–1869), British mathematician and author.
• Thomas W. Thompson (1766–1821), former United States Representative (1805–1807) and Senator (1814–1817) from New Hampshire, former New Hampshire State Legislator

• Thomas Thompson (American author)
• Tommy Thompson (baseball player)
• Thomas Thompson (Toronto) (1803–1868), a Toronto schoolmaster and merchant
• Tommy Thompson (murderer), executed in California for the murder of Ginger Fleischli in 1998
• Thomas D. Thompson, a clarinetist with the Pittsburgh Symphony Orchestra
• Thomas G. Thompson, discoverer of the SS Central America
• Thomas W. Thompson (soldier) (1839–1927), an American Civil War Medal of Honor recipient
• Thomas Williams Thompson (1840–1882), an American Civil War colonel

See also:

• C.R. 'Tommy' Thompson(1895-1966), a WWII British naval officer and Flag Lieutenant.
• Llewellyn "Tommy" E. Thompson, Jr. (1904–1972), former United States Ambassador to the Soviet Union (1957–1962, 1967–1969) and former United States Ambassador to Austria (1955–1957).
• Tom Thomson (1877–1917), a Canadian artist
• Thomas McKean Thompson McKennan (1794–1852), United States Secretary of the Interior and United States Representative from Pennsylvania
• Thomas Thomson, Scottish chemist
• Thomas Thomson (botanist), British botanist