In computing and video games:

• Tk (framework), a GUI software toolkit
• .tk, the top-level domain of Tokelau
• Team killing, used in team-based video gaming; the act of killing one or more of your teammates.
• Tiny Kong, a female Donkey Kong first seen in Donkey Kong Country

In music and film:

• Tsakani Mhinga, South African R&B artist
• TK (Peruvian rock band)
• Tetsuya Komuro, a Japanese musician
• The Killers (band)
• Thoma Kikis
• TK Records
• Tony Kanal
• Tragic Kingdom
• Tynisha Keli
• Tk(rapper), A rapper not signed Erin Moye-Gordon

In other uses:

• Identification number prefix used by Imperial Stormtroopers in Star Wars as well as the 501st Legion
• Taka, currency of Bangladesh
• Taluk, part of districts in India
• Telecine, usually abbreviated as TK instead of TC due to the latter being used to mean time code
• Telekinesis
• Teresa Keiner, a character on Boy Meets World.
• Thymidine kinase (TK), a protein.
• Tim Kennedy, a college hockey player
• TK, the protagonist of Driver: Parallel Lines
• TK-31, the serial number of Elpizo, a main antagonist from Megaman Zero
• T. K. Takaishi, A main character from the Digimon anime
• "To come", phonetic abbreviation used in book publishing and journalism
• Tomato ketchup
• Traditional knowledge
• Tsuyoshi Kohsaka, a Japanese mixed martial arts fighter.
• The IATA Code for Turkish Airlines
• Turkmen language ISO language code (tk).
• Tony Kornheiser, American sports writer and TV personality
• Tom Kenny, best known for his role in SpongeBob SquarePants