It is also synthesized from propionyl CoA, the odd numbered fatty acid which cannot undergo beta-oxidation. Propionyl-CoA is carboxylated to D-methylmalonyl-CoA, isomerized to L-methylmalonyl-CoA, and rearranged to yield succinyl-CoA via a vitamin B12-dependent enzyme. Succinyl-CoA is an intermediate of the citric acid cycle and can be readily incorporated there.
WIPO PUBLISHES PATENT OF NOVOZYMES INC., NOVOZYMES A/ S FOR "POLYPEPTIDES HAVING SUCCINYL-COA:ACETO ACETATE TRANSFERASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME" (DANISH, AMERICAN INVENTORS)
May 10, 2012; GENEVA, May 10 -- Publication No. WO/2012/058566 was published on May 3. Title of the invention: "POLYPEPTIDES HAVING...