In the gastrointestinal tract, the submucosa is the layer of loose connective tissue that supports the mucosa, as well as joins the mucosa to the bulk of underlying smooth muscle (fibers running circularly within layer of longitudinal muscle).
Tiny parasympathetic ganglia are scattered around forming the submucosal plexus (or "Meissner's plexus") where preganglionic parasympathetic neurons synapse with postganglionic nerve fibers that supply the muscularis mucosae.
The submucosa is also identified in endoscopic ultrasound to identify the depth of tumours and to identify other abnormalities. An injection of dye, saline, or epinephrine into the submucosa is imperative in the safe removal of certain polyps.
Endoscopic mucosal resection involves removal of the mucosal layer, and in order to be done safely, a submucosal injection of dye is performed to ensure integrity at the beginning of the procedure.
obliterative muscularization of the small bowel submucosa in Crohn disease: A possible mechanism of small bowel obstruction
Oct 01, 2001; A Possible Mechanism of Small Bowel Obstruction * Context,-The pathology of small bowel obstruction in Crohn disease has not been...
Obliterative muscularization of the small bowel submucosa in crohn disease: a possible mechanism of small bowel obstruction.
Oct 01, 2001; Stricture formation in Crohn disease has been traditionally ascribed to fibrosis of the Submucosa after ulceration. (1-3)...