During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow and the formation of large blood vessels. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life.
In adulthood CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPC) from the bone morrow through a CXCR4 dependent mechanism. It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression.
Oncostatin M regulates mesenchymal cell differentiation and enhances hematopoietic supportive activity of bone marrow stromal cell lines
Nov 01, 2001; SUMMARY Bone marrow stromal cell lines (TBR cell lines) established from temperature-sensitive Simian Virus 40 T-antigen gene...
Dynamics of thymocyte--stromal cell interactions visualized by two-photon microscopy. (Reports).(Statistical Data Included)
Jun 07, 2002; Tissue microenvironments are likely to have a profound impact on lymphocyte behavior, yet most studies of lymphocytes have relied...