St. Louis Blues is a 1939 musical film directed by Raoul Walsh that was set on a Mississippi River showboat. Although the plot was not related to the song, the "St. Louis Blues" was sung as one of the numbers. Artists included jazz singer Maxine Sullivan and composer/singer/actor Hoagy Carmichael. The film starred Dorothy Lamour, Lloyd Nolan, Tito Guízar as Jerome Cowan.
Lamour sang "I Go for That by Matt Malneck, Jr., and Frank Loesser in the film, and had a hit recording with it.