He first appeared in The Cursed Earth epic set in the year 2100. After dying in the Cretaceous era his DNA had been found and he had been cloned for the Dinosaur National Park. Unfortunately the Atomic Wars set the creature loose.
He later re-appeared in Judge Dredd with a recurring storyline "Blood of Satanus" as well as in Nemesis the Warlock Book V and even got his own eponymous story, Satanus Unchained!. Blood of Satanus II and Blood of Satanus III: The Tenth Circle both concern attempts to raise Satanus from Hell, with the latter involving a demonic invasion of Mega-City One. He was finally killed by Judge Dredd.
Relatives of Satanus have played major roles in story arcs in other 2000 AD series: