Santiago Creel Miranda (b. December 11 1954 in Mexico City) is a Mexican politician who served as Secretary of the Interior in the cabinet of President Vicente Fox and is currently a Senator representing the conservative National Action Party (PAN).

Creel received a bachelor's degree in Law from the National Autonomous University of Mexico (UNAM) and subsequently did graduate work at Georgetown University and earned a master's degree at the University of Michigan. His career highlights include running for Head of Government of the Federal District in 2000 (a race he narrowly lost to Andrés Manuel López Obrador). After that he was appointed to the cabinet by President Vicente Fox to serve as Secretary of the Interior, a position he held from December 2000 to June 2005.

On June 1 2005, Creel presented Fox with his resignation in order to seek his party's candidacy for the 2006 presidential election. Creel's main contender for the PAN's candidacy was Felipe Calderón who won the primary elections and went on to become the incumbent President of Mexico.

In 2006 Santiago Creel won a proportional representation seat in the Senate to serve during the 60th and 61st Legislatures (2006-2012). He led the PAN Senate delegation until June 2008.

In 2008 he admitted that he is the father of actress Edith González's daughter Constanza.

See also Creel-Terrazas Family.

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