Sampson County is the birthplace of William R. King, who after spending time in local government continued on to become the 13th US vice-president.
The National Hollerin' Contest, first held in 1969, takes place annually in Spivey's Corner, North Carolina.
Sampson County is the second largest county, in land area, in North Carolina.
The county is drained by the Black and South Rivers, as well as Six Run Creek.
There were 22,273 households out of which 33.40% had children under the age of 18 living with them, 53.60% were married couples living together, 14.30% had a female householder with no husband present, and 27.20% were non-families. 23.70% of all households were made up of individuals and 10.20% had someone living alone who was 65 years of age or older. The average household size was 2.64 and the average family size was 3.09.
In the county the population was spread out with 25.80% under the age of 18, 9.40% from 18 to 24, 29.70% from 25 to 44, 22.30% from 45 to 64, and 12.80% who were 65 years of age or older. The median age was 35 years. For every 100 females there were 98.20 males. For every 100 females age 18 and over, there were 95.90 males.
The median income for a household in the county was $31,793, and the median income for a family was $38,072. Males had a median income of $26,806 versus $20,657 for females. The per capita income for the county was $14,976. About 13.50% of families and 17.60% of the population were below the poverty line, including 21.50% of those under age 18 and 21.50% of those age 65 or over.
Sampson County is also one of the largest producers of hogs in the nation, and second in the state, with a population of over 2 million hogs.