In addition, Levine has guest-starred on Spin City, The Steve Harvey Show, Boston Public, Undeclared, Raising Dad, The Drew Carey Show, That's So Raven, Life as We Know It, That '70s Show, How I Met Your Mother, My Name Is Earl, Entourage, Veronica Mars and Family Guy. His film credits include Not Another Teen Movie, Club Dread, Pulse, Sydney White and Anderson's Cross.
Levine was born in Chicago, Illinois; his father is a dentist (just like the father of his character, Neal Schweiber, in Freaks and Geeks). Levine is the youngest member of the New York Friars' Club. He added an extra 'M' to his name because his actors guild already had a listing for a 'Sam Levine'.