While playing in Shift, Maloney excelled on her school's basketball team, and in 1993, had to decide whether or not to pursue a serious basketball career with college scholarship offers or to continue drumming in her band Shift. Samantha chose to stick with Shift who released two independent records on Equal Vision Records in 1994 and 1995. Two years later, Shift signed to Columbia Records and made their major-label debut album titled, Get In. Following the album's release the band toured diligently.
As her rigorous touring schedule with Mötley Crüe came to a close in January 2001, Maloney made the move from New York to Los Angeles, California where she continued her musical career. In February, she contributed to music for Daryl Hannah's documentary about a stripper called Stripnotes. In May, she worked on The Desert Sessions Vol. 7 & 8 with Josh Homme (Queens of the Stone Age) , Mark Lanegan (Screaming Trees) , and Chris Goss (Masters of Reality). In June, she and Scott Ian from Anthrax composed music for the Mr. Show movie Run Ronnie Run as "Titanica". During this time Maloney also added live drums to the score for the film Black Hawk Down. In 2002, Maloney, alongside Melissa Auf der Maur (Smashing Pumpkins/Hole), Paz Lenchantin (A Perfect Circle), and Radio Sloan (The Need) created a new band called The Chelsea. Sadly, the powerful all-female supergroup only played one show before quickly going their separate ways.
Following this non-stop whirlwind career of working with and for others on their music, the drummer decided to start composing her own album, and in mid-2003 she began to turn down high-profile gigs in order to start her solo project, pausing only to briefly fill in as the drummer for the band Scarling. In 2004, just as she had completed her first batch of songs, Maloney received a call from former Hole frontwoman Courtney Love. Love asked Maloney to fly to France (after drummer Patty Schemel departed for the second time) and add drums to Love's otherwise complete solo debut, America's Sweetheart.
Returning to the States, Maloney was put in charge of assembling Love's live band, reconnecting with guitarist Radio Sloan, finding guitarist Lisa Leveridge and bassist Dvin to form the core of the fierce female band. After playing with the band for a few weeks Love decided to call her new band "The Chelsea” after Maloney’s previous endeavour, yet the band was put on permanent hiatus after a small number of gigs. However, Maloney was soon approached by old friend Josh Homme to drum for his side-project Eagles of Death Metal. Maloney accepted the gig and toured successfully with Eagles of Death Metal opening for Queens of the Stone Age all over the world. Samantha is currently on tour with Electroclash punk artist Peaches' live band, The Herms along with JD Samson and Radio Sloan in support of her 2006 release Impeach My Bush.
She currently resides in Los Angeles, California and is working on new material along with singer Jessicka for Jeffree Star's yet to be titled EP. Maloney was one of the guests to attend the wedding of Jessicka and Christian Hejnal of Scarling. on October 13, 2007 in Los Angeles. She served as one of the bridesmaids.
In 2008 Maloney was one of the contributors to Carrie Borzillo-Vrenna's book Cherry Bomb along with Dita Von Teese, Jessicka, Tori Amos, Cherie Currie of the Runaways, Terri Nunn, Lisa Loeb, Katy Perry, Betsey Johnson, Anna Sui,and Louise Post.