Saint Helena Sound is a coastal inlet in Beaufort and Colleton County, South Carolina. The inlet is located East of Beaufort, between Edisto Island. and Hunting Island. Saint Helena Sound is 7.5 mi/12.1 km wide. The Combahee River empties from the Northwest and the Edisto River and Ashepoo River from the North. The Coosaw River connects its North end with Broad River channel. The Intracoastal Waterway crosses the sound.

See also: Waterways forming and crossings of the Atlantic Intracoastal Waterway

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