He was educated at Emmanuel College, Cambridge, where he was a sizar, from 1649, graduating 1652. He became a Fellow there in 1655, and vicar of Stranground, Huntingdonshire, in 1659. He was deprived in 1662 .
His A Demonstration of the Messias has been identified as a significant influence on the librettist Charles Jennens, in writing the words for the Messiah of Handel. This book also took up suggestions of Joseph Mede on multiple authorship of the Book of Zechariah.
He was killed in the major storm of 26/7 November 1703; he was in bed with his wife in the episcopal palace at Wells when the chimney fell on both of them.