He started his career in his native Nigeria, but his career was nearly derailed when the Nigeria Football Association slammed a five-year ban on him for allegedly assaulting a referee during a Premier League game between his club, Sunshine Stars F.C. , and visiting Enyimba FC. He then played in Benin the next season and switched citizenship the same year.
Among other achievements, Omotoyossi scored the first ever goal for Benin in the World Youth Championship , and equalized for Sheriff in injury time against FC Spartak Moscow in the second qualifying round of the UEFA Champions League. He was signed to Sheriff, the top Moldovan club, in November 2005. In March 2007 he went on trial in Hapoel Kfar Saba, then at the Israeli Premier League, coached by former national team hero, Eli Ohana. Omotoyossi even scored in a Toto Cup game and impressed, but wasn't signed eventually.
In his first season in Allsvenskan, Omotoyossi scored 14 goals in 23 matches. With this effort, he shared the title of top scorer in the league with IFK Göteborg striker Marcus Berg who tallied 14 goals in 17 games. After the group stage of the UEFA Cup 2007-08, he had scored six goals in six matches, which made him top scorer alongside team mate Henrik Larsson and Luca Toni of Bayern Munich. This impressive achievement caught the eye of Dutch side SC Heerenveen, and it was rumoured that they wanted the striker as a replacement for Brazilian striker Afonso Alves who was about to leave. After the January transfer window had shut, it was revealed that Omotoyossi had declined a move to FC Groningen to join fellow Allsvenskan top scorer Marcus Berg, a transfer that Helsingborgs IF manager Bo Nilsson confirmed would have cost the Dutch outfit more than what Sheffield United paid for Luton Shelton when he left Helsingborg for a solid £2 million After poor performances in the UEFA Cup Round of 32 against PSV Eindhoven, the interest from European clubs is said to have cooled down, although it is reported that some Russian and Ukrainean clubs are still on the hunt for the striker.
He is currently one of two forwards in the Benin national football team, scoring against Senegal in a friendly on 7 February 2007 and he also scored against Ivory Coast in their 4-1 loss during the 2008 African Cup of Nations.
Omotoyossi is a devout Muslim and claims to be in possession of only one book - the Quran. In an interview with local newspaper Helsingborgs Dagblad, he compared football players with prostitutes, saying that "we go where there is money"