After the departure of IX and 12 squadrons in 1959, Binbrook housed Gloster Javelin all-weather fighters belonging to 64 squadron, as well as the Central Fighter Establishment. 85 Squadron also moved to Binbrook with a mixture of Canberras and Gloster Meteors in the target facilities role.
From 1965, Binbrook was the home to the English Electric Lightnings of 5 Squadron, joined by the similarly-equipped 11 Squadron in 1972. 5 and 11 were the last two RAF squadrons to employ the Lightning. 5 Squadron re-equipped with the Tornado F3 at RAF Coningsby early in 1988, leaving 11 Squadron to soldier on at Binbrook for a few more months with the remaining few Lightnings in RAF service. When 11 Squadron disbanded (to re-equip with the Tornado F3 at RAF Leeming), the station closed and was subsequently sold off for development.
RAF Binbrook served as the American airbase in the 1989 movie Memphis Belle.