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Pyrrhonism, or Pyrrhonian skepticism, was a school of skepticism founded by Aenesidemus in the first century BC and recorded by Sextus Empiricus in the late 2nd century or early 3rd century AD. It was named after Pyrrho, a philosopher who lived from c. 360 to c. 270 BC, although the relationship between the philosophy of the school and of the historical figure is murky. Pyrrhonism has become influential during the past few centuries when the modern scientific worldview was born.

Whereas 'academic' skepticism, with as its most famous adherent Carneades, claims that "Nothing can be known, not even this", Pyrrhonian skeptics withhold any assent with regard to non-evident propositions and remain in a state of perpetual inquiry. According to them, even the statement that nothing can be known is dogmatic.

Pyrrhonian skepticism is similar to the form of skepticism called Zeteticism promoted by Marcello Truzzi.