Pyrazines
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Wikipedia
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Pyrazine is a heterocyclic aromatic organic compound.
Pyrazine is a symmetrical molecule with point group D2h. It is found in folic acid in the form of pterin. Derivatives like Phenazine are well known for their antitumor, antibiotic and diuretic activity. Pyrazine is less basic in nature than pyridine, pyridazine and pyrimidine. Tetramethylpyrazine is reported to scavenge superoxide anion and decrease nitric oxide production in human polymorphonuclear leukocytes. It is also found on the cigarette additives list.
Synthesis
Many methods exist for the organic synthesis of pyrazine and derivatives. One of them is the Gastaldi synthesis :See also
- Pyrimidine, an analog with the second nitrogen atom in position 3.
- Pyridazine, an analog with the second nitrogen atom in position 2.
- Pyridine, an analog with only one nitrogen atom.
- Benzene, an analog without the nitrogen atoms.
- Simple aromatic rings
- Methoxypyrazines
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